Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

197
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
197
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

300
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
300
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

781
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
781
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

273
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
273
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

500
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
500
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

511
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
511

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The methanolic extract of Byrsonima intermedia mitigates colonic injury in experimental colitis through redox restoration, cytokine modulation, and tissue repair.

Inflammopharmacology·2026
Same author

BCG Vaccination Modulates Long-Term TNF-α and sCD40L in COVID-19: An Exploratory Longitudinal Study.

International journal of general medicine·2026
Same author

Assessment of abdominal symptoms and intestinal inflammation in children and adolescents with cystic fibrosis without highly effective modulator therapy.

Jornal de pediatria·2026
Same author

Pouch cancer in familial adenomatous polyposis. Incidence, risk factors and literature review: a propos of three rare cases.

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery·2026
Same author

Emergency surgical approach for abdominal trauma in a patient with Crohn's disease: case report and literature review.

International journal of surgery case reports·2026
Same author

Evaluation of serum and dietary profiles of vitamin B12 and folate and their association with systemic complications in patients with Crohn's disease.

European journal of clinical nutrition·2026

Related Experiment Video

Updated: Sep 1, 2025

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment
04:05

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment

Published on: May 31, 2024

463

Pouchitis: insight into the pathogenesis and clinical aspects.

Leandro Minatel Vidal de Negreiros1, Lívia Bitencourt Pascoal1, Lívia Moreira Genaro1

  • 1Inflammatory Bowel Disease Research Laboratory, Colorectal Surgery Unit, Department of Surgery, School of Medical Sciences, University of Campinas (Unicamp) Campinas, Brazil.

American Journal of Translational Research
|August 12, 2022
PubMed
Summary

Pouchitis, an inflammation after IPAA surgery for ulcerative colitis (UC) or familial adenomatous polyposis (FAP), affects many UC patients. This review explores its causes, risks, diagnosis, and treatment.

Keywords:
Ulcerative colitisfamilial adenomatous polyposisileal pouch-anal anastomosispouchitis

More Related Videos

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

17.7K
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

2.8K

Related Experiment Videos

Last Updated: Sep 1, 2025

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment
04:05

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment

Published on: May 31, 2024

463
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

17.7K
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

2.8K

Area of Science:

  • Gastroenterology
  • Surgical Pathology
  • Inflammatory Bowel Disease

Background:

  • Ulcerative colitis (UC) and familial adenomatous polyposis (FAP) are distinct conditions.
  • Both may necessitate proctocolectomy with ileal pouch-anal anastomosis (IPAA).
  • Pouchitis, inflammation of the ileal pouch, is a primary complication post-IPAA.

Purpose of the Study:

  • To review the molecular mechanisms underlying pouchitis pathogenesis.
  • To detail risk factors associated with pouchitis development.
  • To outline current diagnostic and treatment strategies for pouchitis.

Main Methods:

  • Literature review of molecular mechanisms.
  • Analysis of risk factors for pouchitis.
  • Synthesis of diagnostic criteria and therapeutic approaches.

Main Results:

  • Pouchitis affects up to 60% of IPAA patients with UC.
  • A very small percentage of FAP patients develop pouchitis.
  • Current understanding of molecular pathogenesis, risk factors, diagnosis, and treatment is summarized.

Conclusions:

  • Pouchitis is a significant complication, particularly in ulcerative colitis patients undergoing IPAA.
  • Further research into molecular mechanisms may improve diagnosis and treatment.
  • Comprehensive management strategies are crucial for patients with pouchitis.