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Updated: Sep 1, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Transition metal-catalyzed regioselective functionalization of carbazoles and indolines with maleimides
Eun Hee Cho1, Muhammad Saeed Akhtar1, Mohammad Aslam1
1School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea. yrlee@yu.ac.kr.
Abstract:
The directing group-assisted regioselective C-H activation of carbazoles and indolines is achieved via transition metal-catalyzed reactions. This C-H functionalization protocol provides a rapid approach to install diversely functionalized succinimide groups at the C-1 position of the carbazole moiety. In addition, this protocol demonstrates the intrinsic reactivity of indolines in providing C-2 succinimide-substituted indoles via cascade direct oxidation and C-H functionalization. This protocol also provides C-7 succinimide-substituted indolines under mild reaction conditions. The features of this reaction include a wide substrate scope and excellent regioselectivity for the installation of the succinimide moiety on biologically interesting molecules.
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