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Is the Choroid Plexus Needed?

Sarah Stricker1,2, Raphael Guzman3,4,5, Thomas Blauwblomme6,7

  • 1Department of Neurosurgery, University Hospital Basel, Basel, Switzerland, sarah.stricker@gmail.com.

Pediatric Neurosurgery
|August 12, 2022
PubMed
Summary
This summary is machine-generated.

Subtotal choroid plexus cauterization (CPC) is a hydrocephalus treatment, but its long-term effects on brain metabolism, neurogenesis, and neuroimmunology remain largely unknown. Further research is crucial to understand potential risks and benefits.

Keywords:
Choroid plexusChoroid plexus cauterizationHydrocephalusVentriculoperitoneal shunt

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Area of Science:

  • Neuroscience
  • Neurosurgery
  • Pediatrics

Background:

  • Choroid plexectomy, evolving into subtotal choroid plexus cauterization (CPC), was historically used for hydrocephalus.
  • CPC was largely abandoned with the advent of shunts but has been reintroduced due to improved endoscopic techniques.
  • The biomolecular consequences of CPC on brain homeostasis, neurogenesis, and neuroimmunology are not well understood.

Purpose of the Study:

  • To investigate the largely unknown biomolecular consequences of subtotal choroid plexus cauterization (CPC).
  • To explore the effects of CPC on metabolic brain homeostasis, neurogenesis, and neuroimmunology.
  • To highlight the need for further research into the long-term outcomes of CPC.

Main Methods:

  • Review of historical and current practices of choroid plexus cauterization.
  • Analysis of existing literature on hydrocephalus pathophysiology and endoscopic techniques.
  • Identification of knowledge gaps regarding the biomolecular and functional consequences of CPC.

Main Results:

  • Subtotal choroid plexus cauterization (CPC) is a viable treatment for hydrocephalus, particularly in underserved regions.
  • The long-term effects of CPC on brain development, neurodegeneration, and inflammation are not fully elucidated.
  • The role of the choroid plexus in neurogenesis and neuroimmunology, and its implications in diseases like Alzheimer's and Multiple Sclerosis, warrant further investigation.

Conclusions:

  • The physiological roles of the choroid plexus in neurogenesis and neuroimmunology necessitate further study regarding CPC's impact.
  • Long-term studies in both pediatric and adult hydrocephalus patients are needed to assess hydrodynamic stabilization and potential neurodegenerative or inflammatory changes.
  • A comprehensive discussion of CPC risks and benefits, including potential implications for brain development and function, is essential when considering this treatment option.