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Monkeypox in-patients with severe anal pain
Frieder Pfäfflin1, Daniel Wendisch1, Roland Scherer2
1Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
Infection
|August 12, 2022
Summary
The current monkeypox outbreak in Berlin significantly impacted patients, predominantly affecting men who have sex with men (MSM) presenting with severe anal pain and ulcers. Findings suggest sexual transmission is a key factor in the spread of monkeypox virus.
Area of Science:
- Infectious Diseases
- Virology
- Public Health
Background:
- Berlin is experiencing a significant outbreak of monkeypox.
- Early clinical data on affected patients are crucial for understanding transmission and disease presentation.
Purpose of the Study:
- To describe the clinical characteristics of the initial monkeypox patients admitted to a Berlin center.
- To investigate the potential role of sexual transmission in the current monkeypox outbreak.
Main Methods:
- Analysis of anamnestic, clinical, and laboratory data from hospitalized patients.
- Clinical examination and laboratory confirmation of monkeypox virus.
Main Results:
- Six male patients who have sex with men (MSM) were hospitalized within two weeks.
- All patients reported recent condomless receptive anal intercourse.
- Severe anal pain, proctitis, and anal/rectal ulcers were common, with monkeypox virus detection.
Conclusions:
- The clinical presentation in these patients suggests a specific proctitis syndrome associated with monkeypox.
- Findings support the hypothesis that sexual transmission is a significant route for the current monkeypox outbreak.
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