Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental differences in the analgesia produced by the central cholinergic system.

R J Hamm, J S Knisely

    Developmental Psychobiology
    |May 1, 1987
    PubMed
    Summary

    Cholinergic system development impacts pain relief. Young rats (10- and 28-day-old) showed no analgesia from oxotremorine, but 3-month-old rats did, indicating functional maturation of central nervous system pain pathways.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat.

    Acta neurochirurgica·2007
    Same author

    Neurobehavioral assessment of outcome following traumatic brain injury in rats: an evaluation of selected measures.

    Journal of neurotrauma·2001
    Same author

    Differential effects of delta 9-THC on spatial reference and working memory in mice.

    Psychopharmacology·2001
    Same author

    Nefiracetam improves Morris water maze performance following traumatic brain injury in rats.

    Pharmacology, biochemistry, and behavior·2001
    Same author

    Subtle alterations in NMDA-stimulated cyclic GMP levels following lateral fluid percussion brain injury.

    Journal of neurotrauma·2001
    Same author

    Postinjury administration of L-deprenyl improves cognitive function and enhances neuroplasticity after traumatic brain injury.

    Experimental neurology·2000

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Developmental Biology

    Background:

    • Cholinergic system plays a crucial role in central nervous system (CNS) functions, including pain modulation.
    • Understanding the ontogenesis of analgesia mediated by the cholinergic system is vital for comprehending pain development.
    • Previous studies suggest neurochemical markers mature early, but functional analgesic capacity may lag.

    Purpose of the Study:

    • To investigate the developmental timeline of cholinergically mediated analgesia in the rat CNS.
    • To determine the age at which central cholinergic pathways become functional for pain relief.
    • To compare neurochemical maturity with functional analgesic capacity.

    Main Methods:

    • Oxotremorine, a muscarinic receptor agonist, was administered to rats of different ages (10-day, 28-day, 3-month-old).

    Related Experiment Videos

  • Methylscopolamine, a peripheral antagonist, was co-injected to isolate central nervous system effects.
  • Analgesia was assessed using the tail-flick test.

    • Main Results:

    • Oxotremorine failed to produce analgesia in 10-day- and 28-day-old rats.
    • A dose-dependent analgesic effect of oxotremorine was observed in 3-month-old rats.
    • Functional analgesic capacity develops later than neurochemical markers of cholinergic receptor function.

    Conclusions:

    • The central cholinergic system's ability to mediate analgesia matures significantly after 28 days of age in rats.
    • Neurochemical assessments of cholinergic receptor function may overestimate the system's functional analgesic capabilities in immature brains.
    • This study highlights a critical developmental window for the maturation of pain modulation pathways.