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Diagnostic Efficiency of Serum-Based Infrared Spectroscopy in Detecting Breast Cancer: A Meta-Analysis
Louise Julie Pabico1, Jennica Naiomi Jaron1, Marc Erickson Mosqueda1
1Department of Biological Sciences, College of Science, University of Santo Tomas, Manila, Philippines.
Background:
The advancement of Fourier transform infrared (FTIR) spectroscopy as a potential diagnostic tool in the clinical setting has been studied over the years, particularly its application in cancer diagnostics.
Objective:
To summarize previous research on FTIR spectroscopy in detecting breast cancer using serum specimens.
Methods:
Related literature was searched and screened from various databases. Relevant data were then extracted, tabulated, and analyzed using Meta-DiSc 1.4 software.
Results:
Sensitivity and specificity rates were 90% to 100% and 80% to 95%, respectively. The area under the receiver operating characteristic curve was at 0.9729, indicating that serum analysis via FTIR spectroscopy can accurately discriminate between healthy individuals and patients with breast cancer.
Conclusion:
Overall, FTIR spectroscopy for breast cancer diagnosis using serum specimens shows promising results. However, further studies are still needed to validate these claims.
