Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Scaling01:26

Scaling

302
In designing and analyzing filters, resonant circuits, or circuit analysis at large, working with standard element values like 1 ohm, 1 henry, or 1 farad can be convenient before scaling these values to more realistic figures. This approach is widely utilized by not employing realistic element values in numerous examples and problems; it simplifies mastering circuit analysis through convenient component values. The complexity of calculations is thereby reduced, with the understanding that...
302
Typical Model Studies01:30

Typical Model Studies

433
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
433
Modeling and Similitude01:12

Modeling and Similitude

324
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
324
Design Example: Creating a Hydraulic Model of a Dam Spillway01:21

Design Example: Creating a Hydraulic Model of a Dam Spillway

284
Scaled hydraulic models of dam spillways provide a practical way to replicate and study the intricate flow dynamics of these structures. Often built to a 1:15 ratio, these models allow for observing critical water behavior, such as velocity distribution, flow patterns, and energy dissipation.
284
Design Example: Aggregate Gradation01:24

Design Example: Aggregate Gradation

146
The right type and quality of aggregates are crucial for concrete as they significantly influence its properties, mix proportions, and cost-effectiveness. If different sources are available for sand, the commonly used fine aggregate in concrete, the selection of sand is primarily based on its gradation.
The grading, or particle-size distribution, of sand is determined using sieve analysis, with standard sizes ranging from 150 μm to 10 mm (ASTM No. 100 sieve to 3⁄8 in. sieve). Sand is...
146

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Terminal Conjugation Enables Nanopore Sequencing of Peptides.

Journal of the American Chemical Society·2026
Same author

Two CTCF motifs impede cohesin-mediated DNA loop extrusion.

Molecular cell·2025
Same author

Delay-facilitated self-assembly in compartmentalized systems.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Topology and kinetic pathways of colloidosome assembly and disassembly.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Robust and resource-optimal dynamic pattern formation of Min proteins in vivo.

Nature physics·2025
Same author

Telomeres stall DNA loop extrusion by condensin.

Cell reports·2025
Same journal

Tau protein as a regulator of mitochondrial function and dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

A scalable, dividing cell model for the robust propagation and quantification of human sporadic Creutzfeldt-Jakob disease prions.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Epigenetic regulation of mesenchymal BMP signaling directs postnatal organ innervation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Single-shot wide-field biochemical imaging at 1 kHz frame rate.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Morphogenesis and topological evolution of a frustrated nematic liquid crystal under confinement.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

B cell-intrinsic CXCR3 drives efficient generation of ectopic pulmonary germinal center responses to influenza A virus infection.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Related Experiment Video

Updated: Sep 1, 2025

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces
06:14

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

6.7K

Bridging scales in a multiscale pattern-forming system.

Laeschkir Würthner1,2, Fridtjof Brauns1,2, Grzegorz Pawlik3

  • 1Arnold Sommerfeld Center for Theoretical Physics, Department of Physics, Ludwig-Maximilians-Universität München, D-80333 München, Germany.

Proceedings of the National Academy of Sciences of the United States of America
|August 12, 2022
PubMed
Summary
This summary is machine-generated.

We developed a new coarse-graining method to study complex biological pattern formation. This approach uses mass conservation to predict pattern dynamics from large-scale protein densities.

Keywords:
in vitro Min systemmultiscale systemspattern formationreaction–diffusion dynamicsreduced dynamics

More Related Videos

Fabrication and Visualization of Capillary Bridges in Slit Pore Geometry
11:20

Fabrication and Visualization of Capillary Bridges in Slit Pore Geometry

Published on: January 9, 2014

6.6K
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

8.8K

Related Experiment Videos

Last Updated: Sep 1, 2025

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces
06:14

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

6.7K
Fabrication and Visualization of Capillary Bridges in Slit Pore Geometry
11:20

Fabrication and Visualization of Capillary Bridges in Slit Pore Geometry

Published on: January 9, 2014

6.6K
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

8.8K

Area of Science:

  • Biological Physics
  • Systems Biology
  • Theoretical Biology

Background:

  • Self-organized pattern formation is crucial for biological processes.
  • Reaction-diffusion models explain spatial structure development but struggle with multiscale dynamics.
  • Biological systems exhibit complex spatiotemporal dynamics and pattern transitions.

Purpose of the Study:

  • To develop a coarse-graining method for multiscale pattern formation.
  • To reconstruct small-scale pattern information from large-scale dynamics using mass conservation.
  • To provide a versatile theoretical framework for complex biological systems.

Main Methods:

  • Developed a semiphenomenological approach exploiting mass conservation.
  • Partitioned domains into coarse-grained regions to determine local dispersion relations.
  • Applied the method to the Min system (protein pattern formation) and validated with simulations and in vitro experiments.

Main Results:

  • Demonstrated that the Min system forms multiscale patterns in heterogeneous geometries.
  • Showed that large-scale protein density evolution reliably predicts pattern-forming dynamics.
  • Confirmed theoretical predictions experimentally through in vitro reconstitution.

Conclusions:

  • The developed coarse-graining method effectively reconstructs pattern information from large-scale dynamics.
  • This approach offers a versatile alternative for systems where analytical coarse-graining is not feasible.
  • The framework is applicable to a wide range of systems governed by conservation laws.