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A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

Adhesive polyethylene glycol-based hydrogel patch for tissue repair.

Chong Shen¹, Yingjun Li¹, Qin Meng¹

¹Key Laboratory of Biomass Chemical Engineering (Education Ministry), College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Colloids and Surfaces. B, Biointerfaces

|August 12, 2022

Summary

This study developed a novel polyethylene glycol (PEG)-based hydrogel tissue patch. This biocompatible adhesive offers strong adhesion and sealing for various tissues, potentially replacing sutures in wound healing.

Keywords:

Adhesive Biocompatibility Hydrogel Organ PEG Tissue repair

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Last Updated: Sep 1, 2025

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Published on: June 14, 2015

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Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Area of Science:

Biomaterials Science
Tissue Engineering
Surgical Innovation

Background:

Current polyethylene glycol (PEG)-based tissue glues lack sufficient strength and cannot replace sutures.
There is a need for advanced wound closure materials with improved adhesion and sealing capabilities.

Purpose of the Study:

To develop and evaluate a novel PEG-based hydrogel tissue patch for sutureless wound repair.
To assess the adhesion strength, sealing ability, and biocompatibility of the developed hydrogel patch on various tissues.

Main Methods:

Fabrication of a PEG-based hydrogel patch using F127-DA hydrogel and PEG-DA as adhesive.
Photocrosslinking of the patch onto tissues using lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) photoinitiator and UV light.
Evaluation of adhesion energy on multiple porcine tissues (skin, lung, heart, liver, kidney, stomach).
Assessment of the patch's ability to seal punctured tissues and its biocompatibility over 2 days.

Main Results:

The hydrogel patch demonstrated strong adhesion to various tissues, with adhesion energies ranging from 36.89 to 85.33 N/m.
The patch effectively sealed punctured tissues, preventing liquid and air leakage.
Good tissue compatibility was observed after 2 days of adhesion on pig skin.

Conclusions:

The developed PEG-based hydrogel tissue patch exhibits robust adhesion and sealing properties for diverse tissues.
This hydrogel patch shows potential as a sutureless, biocompatible adhesive for wound healing applications.
Further research may lead to its clinical use in surgical repair and tissue regeneration.