DIgestive COmplications in DIabetes - the DICODI population study

Area of Science:

• Gastroenterology
• Endocrinology
• Computational Biology

Background:

• Diabetes mellitus (type 1 and type 2) frequently causes gastrointestinal complications such as gastroparesis and gastroenteropathy.
• High prevalence of celiac disease and pancreatic exocrine insufficiency in diabetic patients leads to overlapping symptoms, complicating diagnosis.
• Differentiating these conditions from functional dyspepsia is a significant clinical challenge.

Purpose of the Study:

• To develop a clinical decision-support tool for differentiating underlying diseases in patients with diverse gastrointestinal symptoms.
• To identify risk factors and characterize gastrointestinal complications associated with diabetes.
• To explore biomarkers for autonomic neuropathy in diabetes.

Main Methods:

• An internet-based survey collected patient data and validated symptom scores for gastroparesis, gastroenteropathy, celiac disease, and pancreatic exocrine insufficiency.
• Logistic and multiple regression analyses identified risk factors and complications.
• Cluster analysis and machine learning were employed for symptom classification and diagnosis.

Main Results:

• Gastrointestinal symptoms are a significant concern for individuals with diabetes.
• The study aims to provide estimates of symptom prevalence and identify risk factors for gastrointestinal complications.
• Classifications of gastrointestinal complications will be developed for healthcare provider feedback.

Conclusions:

• The DICODI project, a web-based initiative, aims to detect gastrointestinal complications of diabetes in a real-world setting.
• This project will benefit individuals with diabetes, healthcare professionals, and society by improving diagnosis and management.