Lanostane triterpenoids from Ganoderma lucidum and their inhibitory effects against FAAH
Da-Wei Li1, Min Liu2, Yue-Qi Leng3
1The Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, People's Republic of China; The First Affiliated Hospital of Dalian Medical University, Dalian 116011, People's Republic of China.
Abstract:
Ganoderma lucidum is a famous edible and medicinal fungus. Through a bioactive phytochemical investigation of the ethanolic extracts of the fruiting bodies of G. lucidum, twenty-nine triterpenoids, including eleven previously undescribed triterpenoids, were isolated and characterized based on spectroscopic data. The inhibitory effects of all the triterpenes against fatty acid amide hydrolase (FAAH) were found to be in the range of 30-60% at 100 μM. Methyl ganoderate A displayed the strongest inhibitory activity (61%) against FAAH. Furthermore, all compounds displayed no cytotoxicity against LOVO and MCF-7 human cancer cells. Hence, our present study provides information about G. lucidum as a functional food or pharmaceutical supplement for the treatment of neuroinflammation.
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