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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
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Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
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Nanotechnology based drug delivery systems: Does shape really matter?

Saurabh Shah1, Paras Famta1, Deepkumar Bagasariya1

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.

International Journal of Pharmaceutics
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Nanoparticle shape is crucial for effective nanomedicine delivery. Optimizing nanoparticle geometry enhances therapeutic outcomes by improving targeting, cellular uptake, and drug distribution.

Keywords:
BiofilmBlood-brain barrierNanoparticle geometryPharmacokineticsProtein corona

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Area of Science:

  • Nanomedicine
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Nanomedicine has advanced therapeutics, with factors like size and charge being well-studied.
  • However, nanoparticle shape and geometry require further investigation for optimizing biomedical applications.

Purpose of the Study:

  • To highlight the significance of nanoparticle shape modulation in drug delivery platforms.
  • To guide researchers in selecting ideal nanoparticle morphologies for specific therapeutic implications.

Main Methods:

  • Review and analysis of existing literature on nanoparticle shape.
  • Discussion of shape's impact on organ targeting, cellular internalization, pharmacokinetics, biodistribution, protein corona, RES evasion, and tumor targeting.
  • Exploration of shape transformation and regulatory considerations.

Main Results:

  • Nanoparticle shape significantly influences key delivery parameters, including biodistribution and cellular uptake.
  • Tailoring nanoparticle morphology can overcome current therapeutic limitations.
  • Shape transformation presents a novel avenue for advanced drug delivery.

Conclusions:

  • Strategic selection of nanoparticle shape is essential for maximizing therapeutic efficacy.
  • Further research into nanoparticle geometry and shape transformation is vital for clinical translation.
  • Addressing regulatory aspects of nanoparticle shape is critical for successful nanomedicine development.