Hormesis: Wound healing and keratinocytes

Area of Science:

• Dermal wound healing research
• Cellular biology
• Pharmacology

Background:

• Hormetic dose responses, characterized by biphasic effects (low-dose stimulation, high-dose inhibition), are increasingly recognized.
• These responses are observed across various biological processes and are induced by diverse agents.

Purpose of the Study:

• To investigate the prevalence and role of hormetic dose responses in dermal wound healing.
• To focus on the effects of hormesis on human keratinocyte viability, proliferation, and migration in vitro.
• To explore the underlying signaling pathways mediating these responses.

Main Methods:

• Review of in vitro studies on dermal wound healing.
• Analysis of data on human keratinocyte responses to various agents.
• Examination of signaling pathways involved in hormetic responses.

Main Results:

• Hormetic dose responses are frequently reported in dermal wound healing studies.
• Low-dose stimulation and high-dose inhibition effects were observed on keratinocyte viability, proliferation, and migration.
• Common signaling pathways and their interactions mediate these hormetic effects.

Conclusions:

• Hormesis is a fundamental concept in dermal wound healing.
• Understanding hormetic responses has significant implications for screening therapeutic agents.
• Hormesis-informed strategies may enhance clinical wound healing outcomes.