[Chemotherapy of dysgerminoma]

Area of Science:

• Gynecologic Oncology
• Medical Oncology
• Chemotherapy Research

Background:

• Dysgerminomas are rare malignant germ cell tumors.
• Metastatic disease presents a treatment challenge.
• Primary surgical management is standard, but recurrence necessitates further intervention.

Observation:

• Two patients with metastatic dysgerminoma post-surgery received chemotherapy.
• One patient was treated with chlorambucil monotherapy.
• The second patient received a combination of vinblastine, bleomycin, and cisplatin, followed by irradiation.

Findings:

• Both patients achieved 5-year disease-free survival.
• Chemotherapy demonstrated significant efficacy in treating metastatic dysgerminoma.
• Dysgerminomas exhibit high sensitivity to both chemotherapy and irradiation.

Implications:

• Chemotherapy is a viable and effective treatment for metastatic dysgerminoma.
• Fertility preservation in younger women can be prioritized by using chemotherapy before irradiation.
• Chemotherapy should be considered a primary or second-line treatment option for metastatic dysgerminoma, reserving irradiation for refractory cases.