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Association between early chronic methicillin-susceptible Staphylococcus aureus colonization and lung function in

Birce Sunman1, Ebru Yalcin1, Beste Ozsezen1

  • 1Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ihsan Dogramaci Children's Hospital, Ankara, Turkey.

Pediatric Pulmonology
|August 13, 2022
PubMed

Insights

Early methicillin-susceptible Staphylococcus aureus (MSSA) colonization in children with cystic fibrosis (CF) is linked to worse lung function and more frequent exacerbations by age 8. Further research is needed to confirm causality.

Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases in Cystic Fibrosis
  • Microbiome and Health Outcomes

Background:

  • Early-onset methicillin-susceptible Staphylococcus aureus (MSSA) colonization in children with cystic fibrosis (CF) may impact long-term health.
  • Understanding the effects of early MSSA colonization is crucial for developing targeted interventions in CF care.

Purpose of the Study:

  • To investigate the association between early chronic MSSA colonization and clinical outcomes at 8 years of age in children with CF.
  • To compare lung function, nutritional status, and exacerbation frequency in early-onset versus late-onset MSSA colonization groups.

Main Methods:

  • Retrospective cohort study of 52 children with CF and chronic MSSA colonization.
  • Comparison of lung function (FEV1, FEF25-75, FVC), BMI, and exacerbation frequency at age 8.
  • Groups defined by onset of chronic MSSA colonization: before age 4 (early) vs. age 4-6 (late).

Main Results:

  • Children with early-onset MSSA colonization had significantly lower FEV1 and FEF25-75 at age 8 compared to the late-onset group.
  • Exacerbation frequency between ages 6 and 8 was significantly higher in the early-onset MSSA colonization group.
  • No significant difference in BMI was observed between the early-onset and late-onset groups at age 8.

Conclusions:

  • Early chronic MSSA colonization in children with CF is associated with poorer lung function and increased exacerbations.
  • The findings suggest a potential negative impact of early MSSA colonization on CF pulmonary outcomes.
  • Further research is warranted to establish a definitive cause-and-effect relationship.
Abstract

Keywords:
MSSAchildrencolonizationcystic fibrosislung function

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