Related Experiment Video

Updated: Sep 1, 2025

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.4K

Effect of Electrolyte Imbalance on Mortality and Late Acute Kidney Injury in Hospitalized COVID-19 Patients

Tahereh Sabaghian, Mohamadjavad Honarvar, Seyed Amir Ahmad Safavi-Naini

  • 1Safety Promotion and Injury Prevention Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran. hhatamabadi@yahoo.com.

Iranian Journal of Kidney Diseases
|August 13, 2022
PubMed

Insights

Electrolyte imbalances like hyponatremia and hypernatremia significantly worsen COVID-19 prognosis, increasing mortality and acute kidney injury risk. Monitoring and correcting these imbalances are crucial for hospitalized patients.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) is a multisystem illness impacting various organs.
  • Electrolyte imbalance (EI) is a common complication in hospitalized patients, potentially affecting COVID-19 outcomes.
  • The interplay between EI, renal dysfunction, and COVID-19 prognosis requires further investigation.

Purpose of the Study:

  • To investigate the impact of electrolyte imbalance on the prognosis of hospitalized COVID-19 patients.
  • To determine the association between specific electrolyte abnormalities and outcomes such as acute kidney injury (AKI) and in-hospital mortality.
  • To identify electrolyte imbalances that serve as independent risk factors for poor COVID-19 prognosis.

Main Methods:

  • Retrospective analysis of 499 hospitalized COVID-19 patients without prior chronic kidney disease.
  • Collection of demographic data, laboratory values, and outcomes from hospital information systems.
  • Assessment of serum electrolytes (sodium, potassium, magnesium, calcium, phosphorus) on admission and during hospitalization, with multivariate analyses to adjust for confounders.

Main Results:

  • AKI occurred in 33.7% and mortality in 18.4% of patients.
  • Hyponatremia and hypernatremia on admission were significantly associated with increased mortality.
  • Hyponatremia and hyperphosphatemia on admission were linked to the development of late AKI.

Conclusions:

  • Specific electrolyte imbalances, including hyponatremia, hypernatremia, hyperkalemia, and hyperphosphatemia, are associated with poor COVID-19 prognosis.
  • Physicians should closely monitor and correct electrolyte disturbances in hospitalized COVID-19 patients.
  • Early identification and management of EI can potentially improve outcomes in COVID-19 patients.
Abstract

More Related Videos

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.6K
Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.3K

Related Concept Videos

Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
42
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
52
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
75
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
63
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
55
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
65