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Clinical Features and Adverse Prognostic Indicators in Datura Poisoning in Children

Kamirul Islam1, Nazima Khatun2, Soutrik Seth2

  • 1Department of Pediatrics, Burdwan Medical College, Burdwan, West Bengal. kamirul.islam7@gmail.com.

Indian Pediatrics
|August 13, 2022
PubMed

Insights

Datura intoxication in children can be severe, with delayed treatment, young age, and seizures indicating poor outcomes. Prompt medical care is crucial for managing this poisoning effectively.

Area of Science:

  • Toxicology
  • Pediatric Emergency Medicine
  • Clinical Toxicology

Background:

  • Datura species contain anticholinergic alkaloids, posing a risk of poisoning, especially in children.
  • Understanding the clinical manifestations and prognostic factors of Datura intoxication is vital for timely intervention.

Purpose of the Study:

  • To identify the clinical features of Datura intoxication in pediatric patients.
  • To determine adverse prognostic indicators associated with severe outcomes in Datura-poisoned children.

Main Methods:

  • Retrospective review of 47 pediatric cases of Datura intoxication.
  • Analysis of clinical data, treatment timelines, and patient outcomes.
  • Statistical analysis to identify risk factors for adverse prognosis.

Main Results:

  • 15 (31.9%) children required intensive care, and one (2.1%) fatality occurred.
  • Delayed treatment (time elapsed >3.15 hours) was a significant predictor of adverse outcomes (RR [95% CI]: 9.4 [3.1-28.3]).
  • Younger age (age <9.5 years) and seizure activity were also associated with poorer prognosis (RR [95% CI]: 3.5 [1.5-8.0] and 2.8 [1.4-5.8], respectively).

Conclusions:

  • Datura intoxication presents significant risks in children, necessitating prompt medical evaluation and treatment.
  • Key adverse prognostic indicators include delayed treatment, younger age, and the occurrence of seizures.
  • Early recognition and management of these risk factors can improve patient outcomes in Datura poisoning.

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