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Meconium-Stained Amniotic Fluid: Impact on Prognosis of Neonatal Bacterial Meningitis

Ya-Ting Li1, Cai-Xia Li1, Chu-Jun Huang2

  • 1Department of Pediatrics, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Journal of Tropical Pediatrics
|August 13, 2022
PubMed
Abstract

Insights

Meconium-stained amniotic fluid (MSAF) significantly increases the risk of poor outcomes in neonatal bacterial meningitis (BM). This finding highlights the need for increased vigilance for BM in infants exposed to MSAF.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Pediatric Neurology

Background:

  • Neonatal bacterial meningitis (BM) poses a significant threat to infant health.
  • Limited data exists on the impact of meconium exposure on BM prognosis.
  • Meconium-stained amniotic fluid (MSAF) is a potential risk factor requiring investigation.

Purpose of the Study:

  • To investigate the association between MSAF and the prognosis of neonatal bacterial meningitis.
  • To identify MSAF as a potential risk factor for adverse outcomes in neonatal BM.

Main Methods:

  • Retrospective cohort study of 256 neonates with BM.
  • Comparison of clinical data, laboratory results, and treatment between neonates with and without MSAF.
  • Multivariate logistic regression analysis to determine prognostic factors.

Main Results:

  • A higher rate of poor prognosis was observed in neonates with MSAF (26.1%) compared to those without (12.6%).
  • MSAF was independently associated with a worse prognosis for neonatal BM (adjusted OR, 2.31).
  • Poor prognosis included permanent neurological sequelae and mortality.

Conclusions:

  • MSAF is a significant risk factor associated with poor prognosis in neonatal bacterial meningitis.
  • Increased clinical attention is warranted for neonates with MSAF presenting with or suspected of having BM.
  • Early identification and management of BM in MSAF-exposed infants may improve outcomes.
Keywords:
bacterial meningitismeconium-stained amniotic fluidneonateprognosis

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