Related Experiment Video

Updated: Sep 1, 2025

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies
08:16

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies

Published on: November 5, 2016

7.8K

Regenerative medicine: postnatal approaches

Paul Kwong Hang Tam1, Kenneth Kak Yuen Wong2, Anthony Atala3

  • 1Faculty of Medicine, Macau University of Science and Technology, Macau Special Administrative Region, China; Division of Paediatric Surgery, Department of Surgery, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.

The Lancet. Child & Adolescent Health
|August 13, 2022
PubMed

Insights

Regenerative medicine advances in postnatal approaches use gene, cell, and niche technologies for tissue and organ repair. These innovations offer new treatments for pediatric diseases and conditions affecting all ages.

Area of Science:

  • Regenerative Medicine
  • Paediatric Healthcare
  • Biotechnology

Background:

  • Paediatric regenerative medicine is advancing rapidly, focusing on postnatal therapeutic strategies.
  • New technologies enable the structural and functional restoration of complex biological systems.
  • Organoid and tissue engineering offer models for human diseases and novel treatments.

Purpose of the Study:

  • To review recent advances in postnatal regenerative medicine approaches for paediatric conditions.
  • To highlight the application of gene, cell, and niche-based technologies.
  • To discuss the potential of these technologies in treating both rare and common diseases.

Main Methods:

  • Review of gene, cell, and niche-based technologies.
  • Analysis of organoid and tissue engineering advancements.
  • Examination of preclinical studies in gastrointestinal, respiratory, and genitourinary systems.

Main Results:

  • Successful structural and functional reconstitution of complex cell, tissue, and organ hierarchies.
  • Development of human disease models and novel treatments for paediatric and general populations.
  • Promising preclinical results for gastrointestinal disorders (oesophageal replacement, short bowel syndrome, etc.) and respiratory diseases (lung tissue engineering).

Conclusions:

  • Postnatal regenerative medicine holds significant promise for treating a wide range of paediatric diseases.
  • Tissue engineering and gene/cell therapies are key to addressing complex congenital conditions.
  • Continued research is essential to overcome challenges in regenerative medicine for complex organs like the heart.

More Related Videos

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

14.4K
Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration06:08

Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration

Published on: January 23, 2016

11.4K

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.2K
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.4K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
982
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.2K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
1.8K