Related Experiment Video

Updated: Sep 1, 2025

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
12:43

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

12.4K

Roles of pattern recognition receptors in response to fungal keratitis

Xiaolong Fang1, Huifang Lian2, Shihao Bi3

  • 1The School of Medicine, Nankai University, Tianjin 300071, China; Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin 300020, China; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Life Sciences
|August 13, 2022
PubMed

Insights

Pattern recognition receptors (PRRs) are crucial for innate immunity against fungal keratitis, a leading cause of blindness. Understanding PRR roles and interactions offers potential therapeutic targets for corneal fungal infections.

Area of Science:

  • Immunology
  • Ophthalmology
  • Mycology

Background:

  • Fungal keratitis is a major global cause of blindness with limited treatment options.
  • Pattern recognition receptors (PRRs) are key components of the innate immune system's defense against fungal pathogens.
  • PRRs recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), initiating inflammatory responses.

Purpose of the Study:

  • To review the critical roles of specific PRRs, including C-type lectin-like receptors, Toll-like receptors, and NOD-like receptors, in fungal keratitis.
  • To elucidate the crosstalk and collaborative mechanisms among PRRs in the context of fungal keratitis pathogenesis.
  • To discuss potential therapeutic strategies targeting PRRs for treating corneal fungal infections.

Main Methods:

  • Literature review focusing on the immunological mechanisms of fungal keratitis.
  • Analysis of research on pattern recognition receptors (PRRs) and their involvement in host defense against fungi.
  • Synthesis of current knowledge on PRR signaling pathways and their contribution to disease.

Main Results:

  • PRRs play a significant role in the innate immune response to fungal keratitis.
  • Specific PRRs like CLRs, TLRs, and NLRs are integral to immune regulation in the cornea during fungal infection.
  • Interactions and crosstalk between different PRRs are vital for disease progression and immune defense.

Conclusions:

  • Pattern recognition receptors are central to innate immunity against fungal keratitis.
  • Understanding PRR function and interplay is essential for developing effective treatments.
  • Targeting PRRs presents a promising avenue for novel therapeutic interventions against fungal corneal infections.
Keywords:
C-type lectin-like receptorsFungal keratitisNOD-like receptorsNovel therapy for fungal keratitisPattern recognition receptorsToll-like receptors

More Related Videos

Identification of Post-translational Modifications of Plant Protein Complexes10:07

Identification of Post-translational Modifications of Plant Protein Complexes

Published on: February 22, 2014

24.0K
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

11.7K

Related Concept Videos

Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
2.2K
Cell Signaling in Plants01:25

Cell Signaling in Plants

Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
5.7K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
898
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.9K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.9K