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Updated: Sep 1, 2025

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
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Mitochondrial miRNAs (MitomiRs): Their potential roles in breast and other cancers

Elif Erturk1, Omer Enes Onur2, Oguzhan Akgun2

  • 1Bursa Uludag University, Vocational School of Health Services, 16059, Bursa, Turkey.

Mitochondrion
|August 13, 2022
PubMed

Insights

Mitochondrial microRNAs (mitomiRs) regulate gene expression and mitochondrial function, contributing to breast cancer initiation and progression. This review explains their biogenesis, transport, and role in cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Mitochondrial Biology

Background:

  • Breast cancer is a leading global health concern for women.
  • MicroRNAs (miRNAs) are key regulators of gene expression.
  • Mitochondria, crucial for cellular energy, are increasingly implicated in cancer.

Purpose of the Study:

  • To review miRNA biogenesis and mitochondrial transport pathways.
  • To summarize the role of mitomiRs in breast cancer.
  • To highlight mitomiRs affecting mitochondrial function in cancer progression.

Main Methods:

  • Literature review of miRNA biogenesis.
  • Analysis of miRNA transport mechanisms to mitochondria.
  • Synthesis of studies on mitomiRs in breast cancer.

Main Results:

  • Mitochondria contain specific miRNAs (mitomiRs) that influence cellular functions.
  • MitomiRs can be transported into mitochondria, affecting mitochondrial proteins.
  • Specific mitomiRs are linked to the initiation and progression of breast cancer.

Conclusions:

  • Mitochondrial regulation by mitomiRs is a critical factor in breast cancer.
  • Understanding mitomiR pathways offers potential therapeutic targets.
  • Further research into mitomiRs could advance breast cancer treatment strategies.
Keywords:
Breast CancerMitochondriaMitomiRsmiRNAs

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