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Biomaterial-based 3D bioprinting strategy for orthopedic tissue engineering
1Department of Mechanical Engineering, Pohang University of Science and Technology, 77 Cheongam-ro, Nam-gu, Gyeongsangbuk-do, Pohang 37673, South Korea; EDmicBio Inc., 111 Hoegi-ro, Dongdaemun-gu, Seoul 02445, South Korea.
Acta Biomaterialia
|August 13, 2022
Summary
Three-dimensional (3D) bioprinting advances tissue engineering and regenerative medicine by creating functional tissue constructs. This review explores 3D bioprinting strategies for orthopedic applications, offering insights into future clinical translation.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Biomaterials Science
Background:
- Three-dimensional (3D) bioprinting enables the creation of complex cellular constructs that mimic natural tissue structures and functions.
- This technology holds significant potential for advancing tissue engineering and regenerative medicine, particularly in orthopedic applications.
- Recent innovations focus on developing functional tissue substitutes for musculoskeletal regeneration.
Purpose of the Study:
- To review rational design and biofabrication strategies for 3D bioprinted tissue constructs in orthopedic tissue engineering.
- To elucidate the fundamentals of 3D bioprinting techniques, biomaterial inks, and design principles.
- To summarize recent advances, challenges, and future directions for clinical translation of 3D bioprinted tissues in orthopedics.
Main Methods:
- Review of current literature on 3D bioprinting techniques and biomaterial inks.
- Analysis of design principles and biofabrication strategies for orthopedic tissue constructs.
- Discussion of recent advances, applications, and limitations of 3D bioprinting in orthopedic tissue engineering.
Main Results:
- 3D bioprinting offers diverse strategies for fabricating orthopedic tissue constructs with potential for clinical translation.
- Key considerations include biomaterial selection, printing techniques, and construct design for mimicking native tissue.
- Recent advances show promise for developing patient-specific tissue substitutes for musculoskeletal regeneration.
Conclusions:
- 3D bioprinting is a transformative technology for orthopedic tissue engineering and regenerative medicine.
- Further research into biofabrication strategies and clinical translation is crucial for developing effective orthopedic implants and therapies.
- Customizable 3D bioprinted tissue substitutes present new clinical possibilities for musculoskeletal repair.
