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Combination of microtubule targeting agents with other antineoplastics for cancer treatment

Tingting Liang1, Lu Lu1, Xueting Song1

  • 1Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, Henan Province 475004, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|August 13, 2022
PubMed

Insights

Combining microtubule targeting agents (MTAs) with other anticancer drugs can overcome resistance and reduce toxicity. This review explores MTA combinations for improved cancer treatment efficacy.

Area of Science:

  • Oncology
  • Pharmacology
  • Cancer Biology

Background:

  • Microtubule targeting agents (MTAs) are crucial in cancer therapy.
  • Clinical use of MTAs is hindered by toxicity, resistance, and limited efficacy.

Purpose of the Study:

  • To review combination strategies involving MTAs and other anticancer agents.
  • To highlight methods for overcoming MTA-related challenges in cancer treatment.

Main Methods:

  • Literature review of MTA combinations with various antineoplastics.
  • Analysis of combinations with cytotoxic agents, kinase inhibitors, HDAC inhibitors, and immune checkpoint inhibitors.

Main Results:

  • Combination therapy can mitigate MTA toxicity and overcome multidrug resistance.
  • Synergistic effects observed in combining MTAs with diverse anticancer drug classes.

Conclusions:

  • Combining MTAs with other anticancer drugs offers a promising strategy to enhance cancer treatment outcomes.
  • This review provides valuable insights for developing effective MTA-based combination therapies.
Keywords:
AntitumorCombination therapyMicrotubule targeting agentsResistanceToxicity

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