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Hypertriglyceridemia.

Alan Chait1

  • 1Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, 850 Republican, Box 358062, Seattle, WA 98109, USA.

Endocrinology and Metabolism Clinics of North America
|August 13, 2022
PubMed
Summary
This summary is machine-generated.

Mild to moderate hypertriglyceridemia, a metabolic syndrome component, often stems from genetic factors and increases cardiovascular disease (CVD) risk. Statins are key for prevention, with eicosapentaenoic ethyl esters recommended for high-risk cases.

Keywords:
Acute pancreatitisAngiopoietin-like protein 3Apolipoprotein C3Cardiovascular diseaseChylomicronemiaHypertriglyceridemiaLipoprotein lipase

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Area of Science:

  • Endocrinology
  • Genetics
  • Cardiology

Background:

  • Hypertriglyceridemia is a common condition, often linked to metabolic syndrome.
  • It significantly elevates the risk of cardiovascular disease (CVD).
  • Causes include genetic factors, other conditions, and certain medications.

Purpose of the Study:

  • To review the causes and management of hypertriglyceridemia.
  • To discuss the role of various treatments in preventing cardiovascular disease.
  • To highlight current therapeutic strategies and areas of uncertainty.

Main Methods:

  • Literature review of genetic, metabolic, and clinical studies.
  • Analysis of epidemiological data on hypertriglyceridemia and CVD risk.
  • Evaluation of current treatment guidelines and clinical trial outcomes.

Main Results:

  • Mild to moderate hypertriglyceridemia is typically polygenic.
  • Statins are primary for CVD prevention; eicosapentaenoic ethyl esters are beneficial for very-high-risk patients.
  • The role of fibrates in CVD prevention requires further clarification.

Conclusions:

  • Hypertriglyceridemia management is crucial for metabolic health and CVD risk reduction.
  • Personalized treatment strategies are essential, considering genetic predispositions and risk factors.
  • Further research is needed to define the optimal use of fibrates in CVD prevention.