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Selenium and/or vitamin E upregulate the antioxidant gene expression and parameters in broilers
Fatma Elgendey1, Rasha A Al Wakeel2, Shabaan A Hemeda3
1Genetics and Genetic Engineering, Department of Animal Wealth Development, Faculty of Veterinary Medicine, Benha University, Toukh, 13736, Egypt.
BMC Veterinary Research
|August 13, 2022
Summary
Vitamin E and selenium supplementation in broiler diets enhance antioxidant defenses by increasing serum iron and copper, boosting antioxidant enzyme activity, and upregulating antioxidant gene expression, thereby reducing oxidative stress.
Area of Science:
- Animal Nutrition
- Biochemistry
- Poultry Science
Background:
- Vitamin E and selenium are primary antioxidants protecting against free radicals.
- Broiler diets were supplemented to evaluate their impact on oxidative stress markers.
Purpose of the Study:
- To assess the effects of vitamin E and/or selenium on blood iron and copper levels in broilers.
- To investigate the influence on liver antioxidant status, lipid peroxidation, and related gene expression.
Main Methods:
- Broilers were divided into four dietary groups: control, vitamin E, selenium, and combined vitamin E and selenium.
- Key blood, liver tissue, and gene expression parameters were analyzed.
Main Results:
- Combined vitamin E and selenium significantly increased serum iron and copper levels.
- Supplementation enhanced antioxidant enzyme activity and decreased malondialdehyde (MDA) in liver tissue.
- Gene expression related to antioxidants was significantly upregulated by both supplements.
Conclusions:
- Vitamin E and selenium act as exogenous antioxidants, scavenging free radicals.
- These nutrients also function as gene regulators, enhancing endogenous antioxidant enzyme production.
