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Updated: Sep 1, 2025
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Published on: August 4, 2021
Research progress on ANXA5 in recurrent pregnancy loss
Liying Peng1, Wanli Yang2, Xujing Deng1
1Department of Reproductive Immunology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Maternal and Fetal Medicine, Shanghai First Maternity & Infant Hospital, Shanghai 201204, China.
Recurrent pregnancy loss (RPL) affects 1-5% of women, with unknown causes in 50%. This review examines how ANXA5 gene single nucleotide polymorphisms (SNPs) may contribute to RPL, offering insights for future research.
Area of Science:
- Reproductive Medicine
- Genetics
- Thrombosis
Background:
- Recurrent pregnancy loss (RPL) affects 1-5% of fertile women, with approximately 50% of cases having unknown etiologies.
- Genetic factors, particularly gene polymorphisms within the coagulation pathway, are implicated in thrombotic diseases and may contribute to RPL.
- The ANXA5 gene and its promoter single nucleotide polymorphisms (SNPs) have emerged as a potential factor associated with RPL across diverse populations.
Purpose of the Study:
- To review and synthesize current research on the association between single nucleotide polymorphisms (SNPs) in the ANXA5 gene and recurrent pregnancy loss (RPL).
- To provide a comprehensive overview of the genetic contributions to RPL pathogenesis.
- To guide future research directions in understanding the role of ANXA5 SNPs in RPL.
Main Methods:
- Literature review of studies investigating the correlation between ANXA5 gene SNPs and RPL.
- Analysis of existing research data on genetic polymorphisms and their association with pregnancy loss.
- Synthesis of findings from multiple ethnic groups to assess the generalizability of the association.
Main Results:
- Several single nucleotide polymorphisms (SNPs) within the promoter region of the ANXA5 gene have been reported in association with recurrent pregnancy loss (RPL).
- The association between specific ANXA5 SNPs and RPL has been observed in various racial and ethnic groups.
- The exact mechanisms linking ANXA5 gene variations to RPL pathogenesis require further elucidation.
Conclusions:
- Single nucleotide polymorphisms (SNPs) in the ANXA5 gene represent a significant area of investigation for understanding the genetic basis of recurrent pregnancy loss (RPL).
- Further research is warranted to clarify the functional impact of ANXA5 SNPs on coagulation and their direct role in RPL.
- This review highlights the need for continued genetic research to identify the unknown causes of RPL and inform clinical management.
