Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

712
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
712

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and Safety of Vemircopan in Generalized Myasthenia Gravis: A Randomized Clinical Trial.

JAMA neurology·2026
Same author

Dual-platform metagenomic surveillance distinguishes pathogen and resistome hotspots across agricultural and mixed-use watersheds.

One health (Amsterdam, Netherlands)·2026
Same author

Modulation of sensory attenuation by intensive meditation practice: an active inference perspective.

Neuroscience of consciousness·2026
Same author

Visual information potentiates incremental VOR adaptation.

Journal of neuroengineering and rehabilitation·2026
Same author

The effect of spatial attention on saccadic adaptation.

Journal of vision·2025
Same author

Genomic Drivers of Biofilm Formation in <i>Salmonella</i> Enteritidis and <i>S</i>. Kentucky from Poultry Production.

Microorganisms·2025

Related Experiment Video

Updated: Sep 1, 2025

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

7.6K

Neural substrates of saccadic adaptation: Plastic changes versus error processing and forward versus backward

Camille Métais1, Judith Nicolas2, Moussa Diarra3

  • 1IMPACT Team, Lyon Neuroscience Research Center, INSERM U1028; CNRS UMR5292; University Claude Bernard Lyon 1; 16, av. du Doyen Lépine, 69676, Bron cedex, France.

Neuroimage
|August 14, 2022
PubMed
Summary

This fMRI study reveals distinct brain regions involved in forward and backward saccadic adaptation, differentiating between error processing and oculomotor changes for better understanding of eye movement plasticity.

Keywords:
Eye movementsNeural plasticityOculomotor errorSensorimotor adaptationTarget jumpsfMRI

More Related Videos

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior
05:05

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior

Published on: December 2, 2022

1.7K
An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
09:27

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

4.3K

Related Experiment Videos

Last Updated: Sep 1, 2025

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

7.6K
Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior
05:05

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior

Published on: December 2, 2022

1.7K
An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
09:27

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

4.3K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Ophthalmology

Background:

  • Saccadic eye movement adaptation involves the cerebellum and cortical areas, but specific neural substrates for forward and backward adaptation, and their components, remain unclear.
  • Previous studies lack neuroimaging data differentiating saccade lengthening (forward) and shortening (backward) adaptation, or their error processing and oculomotor components.

Purpose of the Study:

  • To investigate the neural correlates of forward and backward saccadic adaptation using functional magnetic resonance imaging (fMRI).
  • To differentiate the brain regions involved in error processing versus oculomotor changes during saccadic adaptation.
  • To explore hemispheric and directional specificities in saccadic adaptation.

Main Methods:

  • fMRI data acquired from 24 healthy volunteers performing reactive saccades under four conditions: forward (FW), backward (BW), random (RND), and stationary (STA) target jumps.
  • Blood-oxygen-level-dependent (BOLD) signals analyzed using general linear model (GLM) and Multi-Variate Pattern Analyses (MVPA) on 34 regions of interest (ROIs).
  • Oculomotor behavior recorded to confirm successful adaptation induction.

Main Results:

  • MVPAs identified distinct ROIs for adaptation (occipital cortex, MT/MST, FEF, pallidum), error processing (occipital cortex, PEF, precuneus, MCC, cerebellum), and direction-specific adaptation (occipital cortex, MT/MST, pallidum).
  • GLM analysis supported PEF involvement in error processing (RND vs. STA) and occipital cortex involvement in direction-specific adaptation (FW/BW vs. STA).
  • Oculomotor data confirmed successful forward and backward saccadic adaptation.

Conclusions:

  • The cerebral cortex plays a significant role in saccadic adaptation, interacting with the cerebellum via feedback and feedforward mechanisms.
  • This study elucidates distinct neural pathways for forward and backward saccadic adaptation, including specific regions for error processing and directional control.
  • Findings provide a basis for refining conceptual models of oculomotor plasticity and its relationship with spatial cognition.