Radiological outcome of bone disease in multiple myeloma patients pre- and post therapy: A single center experience
Somaya A Aljohani1, Israa H Saib1, Ghulam Shah Syed1
1From the Department of Internal Medicine (Aljohani, Alsalman, Ozair), King Abdulaziz Medical City Ministry of National Guard - Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences; from the Department of Nuclear Medicine (Saib, Syed), King Abdulaziz Medical City Ministry of National Guard - Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences; from the Division of Adult Hematology, Department of Oncology (Alhejazi, Alaskar, Gmati), King Abdulaziz Medical City Ministry of National Guard - Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences; from the Department of Biostatistics (Vishwakarm), King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences; and from the Clinical Trial Services (Mendoza), King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Objectives:
To find any correlation between the clinical response as per International Working Myeloma Group (IWMG) response criteria and the radiological response at the end of treatment.
Methods:
A retrospective cohort study was conducted, total of 39 patients whom diagnosed with multiple myeloma (MM) between January 2010 and December 2018 and fulfilled the study criteria were included.
Results:
The high sensitivity and specificity of positron emission tomography/computed tomography (PET/CT) in detecting osteolytic myeloma lesions in the bones was strongly emphasized in our study. Follow up PET/CT, we found that while 17 patients showed complete remission in PET/CT, and 14 of these of patients demonstrated a complete clinical response at end of therapy assessment.
Conclusion:
Although we did not find a statistically significant correlation between the response versus metabolic activity and the number of bone/bone marrow lesions, however, our study was limited by the absence of clear criteria for defining disease response in PET/CT in MM patients. Further prospective analysis would be needed to establish a defined criterion.
