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Updated: Sep 1, 2025
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A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
Published on: July 2, 2014
20.4K
Neuropathology of the temporal lobe
Susana Boluda1, Danielle Seilhean1, Franck Bielle1
1Sorbonne Université, INSERM, CNRS, UMR S 1127, Paris Brain Institute, ICM, Paris, France; Neuropathology Department, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, AP-HP, Paris, France.
Handbook of Clinical Neurology
|August 14, 2022
Summary
Temporal lobe neuropathology is crucial for understanding inflammatory, epilepsy, and neurodegenerative diseases. Key lesions and markers aid diagnosis, revealing interdependencies between these conditions.
Area of Science:
- Neuropathology
- Neuroscience
- Pathology
Background:
- The temporal lobe is central to understanding diverse neurological diseases.
- Focus on inflammatory, epilepsy, and neurodegenerative conditions impacting the temporal lobe.
Purpose of the Study:
- To detail neuropathological findings in temporal lobe diseases.
- To correlate histological, immunohistochemical, and molecular data with clinical and radiological presentations.
Main Methods:
- Review of histological lesions and immunohistochemical markers.
- Analysis of molecular alterations in temporal lobe pathologies.
- Integration of epidemiological, clinical, and radiological data.
Main Results:
- Detailed examination of infectious and autoimmune encephalitides.
- Comprehensive review of temporal lobe epilepsy (TLE) pathologies, including hippocampal sclerosis and developmental abnormalities.
- Discussion of Alzheimer's disease, frontotemporal lobar degeneration, and other neurodegenerative conditions affecting the temporal lobe.
Conclusions:
- Neuropathological examination of the temporal lobe is vital for diagnosing and managing a spectrum of diseases.
- Interdependencies exist between inflammatory, epilepsy, and neurodegenerative processes within the temporal lobe.
Keywords:
AlzheimerEpilepsyFrontotemporal lobar degenerationHerpes virusHippocampal sclerosisLimbic encephalitisNeurodegenerativeSARS-Cov2TDP-43TumorsMore Related Videos
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