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Updated: Sep 1, 2025

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Published on: January 10, 2013
Regulation of breathing by cardiopulmonary afferents
1Department of Medicine (Pulmonary), University of Louisville, and Robley Rex VA Medical Center, Louisville, KY, United States.
Abstract:
This chapter broadly reviews cardiopulmonary sympathetic and vagal sensors and their reflex functions during physiologic and pathophysiologic processes. Mechanosensory operating mechanisms, including their central projections, are described under multiple sensor theory. In addition, ways to interpret evidence surrounding several controversial issues are provided, with detailed reasoning on how conclusions are derived. Cardiopulmonary sensory roles in breathing control and the development of symptoms and signs and pathophysiologic processes in cardiopulmonary diseases (such as cough and neuroimmune interaction) also are discussed.
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