When Asthma and Chronic Obstructive Pulmonary Disease Overlap; Current Knowledge and Unmet Needs

Area of Science:

• Pulmonology
• Respiratory Medicine
• Clinical Medicine

Background:

• Asthma and COPD are prevalent respiratory diseases.
• A significant overlap exists between asthma and COPD, termed asthma-COPD overlap (ACO).
• ACO is associated with increased patient morbidity compared to asthma or COPD alone.

Purpose of the Study:

• To review the current understanding of asthma-COPD overlap (ACO).
• To identify knowledge gaps in ACO definition, pathophysiology, and clinical features.
• To guide future research directions for optimal ACO management.

Main Methods:

• Literature review of existing studies on asthma-COPD overlap.
• Analysis of current expert opinions and strategy documents.
• Synthesis of available data on ACO epidemiology and clinical impact.

Main Results:

• The definition, pathophysiology, and clinical characteristics of ACO remain subjects of ongoing research and debate.
• Patients with ACO exhibit greater morbidity than those with isolated asthma or COPD.
• Limited evidence exists regarding the most effective therapeutic strategies for ACO.

Conclusions:

• Further investigation is crucial to establish a clear definition and understanding of ACO.
• Targeted research is needed to develop evidence-based treatment guidelines for ACO patients.
• Addressing knowledge gaps in ACO will improve patient outcomes and clinical management.