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Exploring SARS-CoV2 host-pathogen interactions and associated fungal infections cross-talk: Screening of targets and

Abdul Arif Khan1, Sudhir K Jain2, Mahendra Rai3,4

  • 1Division of Microbiology, ICMR-National AIDS Research Institute, Pune, Maharashtra, India.

Computational and Structural Biotechnology Journal
|August 15, 2022
PubMed

Insights

Opportunistic fungal infections linked to COVID-19 present challenges. This study identifies key host targets, including CARD9 and CYP51A1, involved in SARS-CoV-2 interactions, aiding in managing these fungal coinfections.

Area of Science:

  • Mycology
  • Virology
  • Immunology
  • Computational Biology

Background:

  • COVID-19 has been associated with opportunistic fungal infections, posing significant clinical challenges.
  • Understanding the molecular basis of these coinfections is crucial for effective management.
  • Existing research has identified some host targets implicated in fungal infections among COVID-19 patients.

Purpose of the Study:

  • To screen and identify common host targets involved in COVID-19-associated opportunistic fungal infections.
  • To investigate the interaction of SARS-CoV-2 with these host targets.
  • To explore associated signaling pathways for potential therapeutic strategies.

Main Methods:

  • Utilized biological databases to screen host targets for fungal infections and SARS-CoV-2 host-pathogen interactions.
  • Employed Venn diagrams to identify common host targets across different fungal infections.
  • Constructed interaction networks using STRING and performed pathway enrichment analysis.

Main Results:

  • Identified six common host targets in all studied fungal infections.
  • Found CARD9 and CYP51A1 to be host targets interacting with SARS-CoV-2.
  • Revealed signaling pathways, such as integrin signaling, associated with SARS-CoV-2 host-pathogen interactions.

Conclusions:

  • Several host targets are implicated in SARS-CoV-2-associated fungal infections.
  • CARD9 and CYP51A1 represent potential targets for further investigation.
  • Findings suggest avenues for developing management strategies against these coinfections.
Keywords:
Biological networkCOVID-19FungiPandemicPathogenesis

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