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Poisoning with dextropropoxyphene in Denmark.

E Segest

    Human Toxicology
    |May 1, 1987
    PubMed
    Summary

    Dextropropoxyphene poisoning cases, both fatal and non-fatal, are increasing in Denmark, particularly in Copenhagen. Poisonings disproportionately affect vulnerable populations and often involve other substances like alcohol.

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    Area of Science:

    • Toxicology
    • Public Health
    • Pharmacovigilance

    Background:

    • Rising sales of dextropropoxyphene in Denmark correlate with an increase in poisoning incidents.
    • Poisoning cases are concentrated in the Copenhagen municipality.
    • Dextropropoxyphene poisonings disproportionately affect socially and mentally encumbered individuals.

    Purpose of the Study:

    • To analyze trends and characteristics of dextropropoxyphene poisoning in Denmark.
    • To identify risk factors and contributing elements in dextropropoxyphene-related poisonings.
    • To evaluate the outcomes and mortality rates associated with dextropropoxyphene overdose.

    Main Methods:

    • Analysis of reported fatal and non-fatal hospitalized poisoning cases from the National Board of Health in 1984.
    • Examination of case demographics, geographical distribution, and co-ingested substances.
    • Assessment of poisoning intent (suicide, accidental, uncertain) and patient mental state.

    Main Results:

    • 124 fatal and 297 non-fatal cases reported in 1984, considered minimum figures.
    • Higher incidence in Copenhagen; increased risk in socially/mentally vulnerable groups.
    • Suicidal/impulsive poisonings more common in non-normal individuals; co-ingestion with alcohol frequent (over 50%).

    Conclusions:

    • The mortality rate for dextropropoxyphene poisonings reaching medical care is 3.6%, lower than other studies, but many cases are fatal upon discovery.
    • Serious sequelae from non-fatal poisonings are rare.
    • Public health interventions are being implemented to mitigate poisoning cases.

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