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Updated: Sep 1, 2025

Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
A progressing inflammatory pulmonary infiltrate in a patient with hyper IgE syndrome
Samal Jakobsen1, Ole Hilberg2, Carsten Schade Larsen3
1Department of Pulmonology, Aarhus University Hospital, Aarhus, Denmark.
Abstract:
A young man known with autosomal dominant hyper IgE syndrome and changes on his chest radiograph was presumed to be infected with Aspergillus and treated with antifungal medicine for 11 months without effect. Positron emission tomography/computed tomography imaging was suggestive of Aspergilloma but bronchoalveolar lavage cultures, cytology as well as biochemistry were negative for Aspergillus. Finally, a transthoracic computed tomography-guided biopsy did not support the diagnosis of fungal infection as only chronic inflammatory changes were found. The patient was treated with Prednisolone after which the changes on his chest X-ray regressed.
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