Recent Progress Toward Imaging Application of Multifunction Sonosensitizers in Sonodynamic Therapy

Area of Science:

• Oncology
• Biomedical Engineering
• Nanotechnology

Background:

• Sonodynamic therapy (SDT) is a non-invasive, ultrasound-activated cancer treatment utilizing sonosensitizers.
• Combining diagnostic and therapeutic modalities can improve anticancer outcomes.
• Sonosensitizers are key components of SDT, with ongoing research focused on optimizing their function and integrating them with other medical fields.

Purpose of the Study:

• To review the combined use of SDT and imaging in cancer treatment over the past five years.
• To explore the development of multifunctional sonosensitive particles for integrated diagnosis and therapy.
• To provide design references for future SDT combined imaging research and clinical applications.

Main Methods:

• Literature review of articles published in the last five years on SDT and cancer imaging.
• Development and evaluation of multifunctional sonosensitive particles.
• Assessment of cellular and animal imaging using these particles.
• Analysis of SDT cell uptake and antitumor efficacy in various tumor models.

Main Results:

• Multifunctional sonosensitive particles successfully integrate imaging and SDT for precision medicine.
• These particles enhance SDT cell uptake and antitumor efficacy.
• Demonstrated utility in both cellular and animal imaging studies.
• Provided data and design insights for future research.

Conclusions:

• The integration of imaging with SDT using multifunctional sonosensitive particles represents a significant advancement in cancer therapy.
• This approach facilitates precision medicine by combining diagnosis with treatment.
• The findings support further development and clinical translation of SDT combined with imaging technologies.