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Clinical Efficacy of Interventional Therapy on Lower Extremity Arteriosclerosis Obliterans and Prognostic Factors

Deshuang Xiao1, Jun Song1

  • 1General Surgery, The First People's Hospital of WenLing, No. 333, Chuanan Road, Wenling City, 317500 Zhejiang Province, China.

Computational and Mathematical Methods in Medicine
|August 15, 2022
PubMed

Insights

Interventional therapy improves short-term outcomes for lower extremity arteriosclerosis obliterans (LEASO). However, long-term efficacy is similar to conservative treatment, with higher costs for interventional approaches.

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Peripheral Artery Disease

Background:

  • Lower extremity arteriosclerosis obliterans (LEASO) significantly impacts patient mobility and quality of life.
  • Effective therapeutic strategies are crucial for managing LEASO and preventing adverse outcomes.

Purpose of the Study:

  • To analyze the clinical efficacy of interventional therapy compared to conservative therapy for LEASO.
  • To identify prognostic factors influencing patient outcomes in LEASO.

Main Methods:

  • Retrospective analysis of 122 LEASO patients (March 2017-March 2019).
  • Comparison of short-term (12 weeks) and long-term (3 years) outcomes between conservative (n=72) and interventional (n=50) groups.
  • Cox regression analysis for prognostic factors and comparison of adverse events, hospital stay, cost, claudication distance, and ankle-brachial index.

Main Results:

  • Interventional therapy showed higher short-term efficacy but similar long-term clinical efficacy compared to conservative therapy.
  • The conservative group had longer hospital stays and lower costs but poorer claudication distance and ankle-brachial index.
  • Mortality, amputation, and restenosis rates were similar between groups; age and conservative therapy were independent risk factors for prognosis.

Conclusions:

  • Interventional therapy offers significant short-term benefits for LEASO patients.
  • Long-term outcomes are comparable, but interventional therapy incurs higher costs.
  • Treatment selection should consider patient economic status and individual prognosis.
Abstract

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