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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

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Contemporary survival and anticoagulation of patients with atrial fibrillation: A community based cohort study in

Yong Wei1, Qingye Zeng1, Lidong Cai1

  • 1Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Cardiovascular Medicine
|August 15, 2022
PubMed

Insights

This study reveals that age, AF subtype, and prior myocardial infarction are key risk factors for death in Chinese atrial fibrillation patients. Oral anticoagulant underuse and ischemic stroke remain significant concerns.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Limited understanding of mortality patterns in Chinese patients with atrial fibrillation (AF).
  • Need to identify contemporary survival rates and risk factors for death in this population.

Purpose of the Study:

  • To assess the current survival status of patients with atrial fibrillation in China.
  • To explore and identify significant risk factors associated with mortality in AF patients.

Main Methods:

  • Prospective, community-based cohort study design.
  • Inclusion of 559 AF patients with a median age of 76 years.
  • Follow-up duration of 66 months (July 2015 - December 2020).

Main Results:

  • 200 deaths observed, with heart failure, ischemic stroke, and cancer as leading causes.
  • Significant risk factors for all-cause death included older age, AF subtype, prior myocardial infarction, previous tumor, and hypoglycemic therapy.
  • Protective factors against death were higher body weight and calcium channel blocker (CCB) use.

Conclusions:

  • Ischemic stroke remains a primary cause of death among AF patients in China.
  • Oral anticoagulant (OAC) therapy is significantly underutilized in this patient group.
  • Key independent risk factors for mortality identified: age, AF subtype, prior tumor, prior myocardial infarction, hypoglycemic therapy, low body weight, and lack of CCB use.
Abstract

Keywords:
anticoagulationatrial fibrillationmortalitystrokesurvival

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