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Updated: Sep 1, 2025

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

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Electrocardiographic and cardiometabolic risk markers of left ventricular diastolic dysfunction in physically active

Pang-Yen Liu1,2, Kun-Zhe Tsai1,3, Wei-Chun Huang4,5

  • 1Department of Medicine, Hualien Armed Forces General Hospital, Hualien City, Taiwan.

Frontiers in Cardiovascular Medicine
|August 15, 2022
PubMed

Insights

Central obesity and specific electrocardiogram (ECG) markers are associated with left ventricular diastolic dysfunction (LVDD) in physically active young Asian men. These findings aid in identifying LVDD risk in this population.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Sports Medicine

Background:

  • Left ventricular diastolic dysfunction (LVDD) prevalence and associated risk factors in physically active young adults remain under-researched.
  • Understanding these associations is crucial for early detection and prevention strategies.

Purpose of the Study:

  • To investigate the link between cardiometabolic risk factors, electrocardiogram (ECG) markers, and LVDD in physically active Asian young adults.
  • To identify specific markers that can predict LVDD in this demographic.

Main Methods:

  • A cohort of 2,019 Taiwanese military men (aged 18-43 years) underwent comprehensive assessments, including anthropometrics, hemodynamics, blood markers, and physical fitness tests (3,000-m run).
  • LVDD was diagnosed using established echocardiographic criteria.
  • Multiple logistic regression analyses were performed, adjusting for covariates, to determine associations between cardiometabolic/ECG markers and LVDD.

Main Results:

  • The prevalence of LVDD was 4.16%.
  • Central obesity (waist circumference ≥ 90 cm) was identified as an independent predictor of LVDD (OR: 2.97).
  • Specific ECG markers, including left atrial enlargement (OR: 2.98) and incomplete right bundle branch block/intraventricular conduction delay (OR: 1.94), were also significantly associated with LVDD.

Conclusions:

  • Central obesity and certain ECG abnormalities are valuable indicators for identifying LVDD in physically active young Asian males.
  • These findings highlight the importance of screening for central obesity and specific ECG findings in this population to detect LVDD early.
Abstract

Keywords:
cardiometabolic risk factorselectrocardiographyleft ventricular diastolic dysfunctionphysical fitnessyoung adult

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