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Effectiveness of Laparoscopic Cholecystectomy in Patients with Gallbladder Stones with Chronic Cholecystitis
Leiping Rao1, Guoqing Zhou1, Yongzhong Gao1
1Department of Hepatobiliary and Pancreatic Surgery, Jinshan Branch of Shanghai the Sixth People's Hospital, Shanghai 201599, China.
Insights
Laparoscopic cholecystectomy is effective for gallbladder stones and chronic cholecystitis, reducing recovery time and inflammation. This minimally invasive approach offers less trauma and high safety compared to small-incision surgery.
Area of Science:
- Gastroenterology
- Minimally Invasive Surgery
- Surgical Outcomes
Background:
- Gallbladder stones and chronic cholecystitis are common conditions requiring surgical intervention.
- Traditional surgical methods can involve significant patient recovery times and potential complications.
Purpose of the Study:
- To compare the effectiveness of laparoscopic cholecystectomy versus small-incision cholecystectomy.
- To evaluate key outcome measures including operative time, inflammatory markers, and gastrointestinal function.
Main Methods:
- A randomized controlled trial involving 90 patients with gallbladder stones and chronic cholecystitis.
- Patients were assigned to either small-incision or laparoscopic cholecystectomy.
- Outcome measures included operation time, bleeding, hospital stay, inflammatory markers (CRP, IL-6, TNF-α), and gastrointestinal hormones (GAS, VIP, MOT).
Main Results:
- Laparoscopic cholecystectomy demonstrated significantly shorter operation times and hospital stays.
- Reduced intraoperative bleeding and lower postoperative inflammatory markers (CRP, IL-6, TNF-α) were observed with laparoscopy.
- Laparoscopic surgery led to improved gastrointestinal hormone levels (GAS, VIP, MOT) and a lower incidence of adverse events.
Conclusions:
- Laparoscopic cholecystectomy is an effective treatment for gallbladder stones and chronic cholecystitis, offering benefits such as reduced operative time, hospital stay, and inflammation.
- This approach enhances gastrointestinal function with less surgical trauma and high safety.
- Further clinical trials are recommended before widespread adoption.
Objective:
To assess the effectiveness of laparoscopic cholecystectomy in patients with gallbladder stones and chronic cholecystitis.
Methods:
From July 2018 to January 2020, 90 patients with gallbladder stones and chronic cholecystitis assessed for eligibility were recruited and concurrently assigned (1 : 1) to receive either small-incision cholecystectomy (observation group) or laparoscopic cholecystectomy (experimental group). Outcome measures included operation time, intraoperative bleeding volume, postoperative hospital stay, c-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-α (TNF-α), gastrin (GAS), vasoactive intestinal peptide (VIP), motilin (MOT), and adverse events.
Results:
Patients given laparoscopic cholecystectomy showed lower levels of operation-related indices versus those receiving small-incision cholecystectomy (P < 0.05). Laparoscopic cholecystectomy resulted in lower postoperative levels of CRP, IL-6, and TNF-α in the patients versus small-incision cholecystectomy (P < 0.05). Patients receiving laparoscopic cholecystectomy showed better GAS, VIP, and MOT levels than those receiving small-incision cholecystectomy (P < 0.05). The eligible patients after laparoscopic cholecystectomy had a significantly lower incidence of adverse events versus those after small-incision cholecystectomy (P < 0.05).
Conclusion:
Laparoscopic cholecystectomy effectively shortens the operative time and length of hospital stay in patients with gallbladder stones and chronic cholecystitis, reduces intraoperative bleeding, attenuates the inflammatory response, and enhances the gastrointestinal function, with less surgical trauma and high safety. Clinical trials are, however, required prior to promotion.
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