A multicenter prospective cohort study of cardiac ultrasound phenotypes in patients with sepsis: Study protocol for a
Hongxuan Zhang1, Xiaoting Wang2, Wanhong Yin3
1The Third Department of Critical Care Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fujian Provincial Center for Critical Care Medicine, Fujian Provincial Key Laboratory of Critical Care Medicine, Fuzhou, China.
Insights
Early identification of septic cardiomyopathy phenotypes using ultrasound can improve sepsis patient outcomes. This study clarifies the relationship between ultrasound phenotypes and prognosis, aiding early intervention and reducing mortality.
Area of Science:
- Critical Care Medicine
- Cardiology
- Diagnostic Imaging
Background:
- Sepsis-induced cardiomyopathy increases patient mortality.
- Diagnostic criteria for septic cardiomyopathy are not unified, complicating clinical management.
- Early identification and intervention are crucial for sepsis patients.
Purpose of the Study:
- To clarify the relationship between ultrasound phenotypes of septic cardiomyopathy and patient prognosis.
- To provide evidence for early identification and intervention strategies.
- To establish a standard method for assessing septic cardiomyopathy using ultrasound.
Main Methods:
- Multicenter, prospective cohort study of adult sepsis patients meeting Sepsis 3.0 criteria.
- Recording of clinical data and echocardiographic measurements at 2 hours, 24 hours, 72 hours, and day 7 post-admission.
- Statistical analysis of phenotype prevalence and association with prognosis.
Main Results:
- Prevalence of different septic cardiomyopathy phenotypes will be described.
- Association between each phenotype and patient prognosis will be analyzed.
- Comparison of prognosis between normal, suppressed, and hyperdynamic cardiac phenotypes.
Conclusions:
- Standardized ultrasound assessment of septic cardiomyopathy is needed.
- Understanding phenotype-prognosis relationships will guide hemodynamic management.
- This research promotes critical care ultrasound application in sepsis management.
Background:
Sepsis-induced cardiomyopathy significantly increased the mortality of patients with sepsis. The diagnostic criteria for septic cardiomyopathy has not been unified, which brings serious difficulties to clinical treatment. This study aimed to provide evidence for the early identification and intervention in patients with sepsis by clarifying the relationship between the ultrasound phenotype of septic cardiomyopathy and the prognosis of patients with sepsis.
Methods:
This was a multicenter, prospective cohort study. The study population will consist of all eligible consecutive patients with sepsis or septic shock who meet the Sepsis 3.0 diagnostic criteria and were aged ≥18 years. Clinical data and echocardiographic measurements will be recorded within 2 h, at the 24th hour, at the 72nd hour, and on the 7th day after admission. The prevalence of each phenotype will be described as well, and their association with prognosis will be analyzed statistically.
Discussion:
To achieve early recognition, prevent reinjury, achieve precise treatment, and reduce mortality in patients with sepsis, it is important to identify septic cardiac alterations and classify the phenotypes at all stages of sepsis. First, there is a lack of studies on the prevalence of each phenotype in Chinese populations. Second, each phenotype and its corresponding prognosis are not clear. In addition, the prognosis of patients with normal cardiac ultrasound phenotypes vs. those with suppressed or hyperdynamic cardiac phenotypes is unclear. Finally, this study was designed to collect data at four specific timing, then the timing of occurrence, duration, changes over time, impact to outcomes of each phenotype will probably be found. This study is expected to establish a standard and objective method to assess the ultrasound phenotype of septic cardiomyopathy due to its advantages of visualization, non-invasiveness and reproducibility, and to provide more precise information for the hemodynamic management of septic patients. In addition, this research will promote the clinical application of critical care ultrasound, which will play an important role in medical education and make ultrasound the best method to assess cardiac changes in sepsis.
Trial Registration:
https://clinicaltrials.gov/ct2/show/NCT05161104, identifier NCT05161104.
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