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Hotspots and future directions in rheumatoid arthritis-related cardiovascular disease: A scientometric and
Pengfei Wen1, Pan Luo1, Binfei Zhang1
1Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Shaanxi, China.
Insights
Research on cardiovascular diseases (CVD) in rheumatoid arthritis (RA) is growing rapidly. Future studies will likely focus on the safety and mechanisms of anti-rheumatoid drugs, particularly targeted synthetic DMARDs.
Area of Science:
- Rheumatology
- Cardiology
- Bibliometrics
Background:
- Cardiovascular disease (CVD) poses a significantly higher risk to patients with rheumatoid arthritis (RA) compared to the general population.
- Despite extensive research, a systematic scientometric analysis of RA-related CVD has been lacking.
- This study addresses this gap by visualizing the knowledge structure and identifying research trends in RA-CVD.
Purpose of the Study:
- To conduct a scientometric analysis of research on cardiovascular diseases (CVD) in rheumatoid arthritis (RA).
- To visualize the knowledge structure, identify research trends, and pinpoint hotspots in the field of RA-CVD.
- To map the global research landscape, including key countries, institutions, and authors.
Main Methods:
- A systematic literature search was performed on articles and reviews published between 2001 and 2021 from the Web of Science Core Collection.
- CiteSpace and VOSviewer software were employed for bibliometric analysis and visualization of networks (countries, institutions, authors, references, keywords).
- Statistical analysis included curve fitting and correlation analysis using SPSS and Microsoft Excel.
Main Results:
- A total of 2,618 publications were analyzed, showing a significant annual increase in research output on RA-CVD.
- North America, Europe, and East Asia are leading regions, with the United States being the most prolific country.
- Key research themes evolved from clinical features and mechanism exploration to anti-tumor necrosis factor therapy, risk factors, and antirheumatic drug safety.
Conclusions:
- Research on RA-related CVD is a flourishing field with increasing publication output.
- Future research is expected to concentrate on the cardiovascular safety and pharmacological mechanisms of anti-rheumatoid drugs, particularly targeted synthetic DMARDs.
Background:
The morbidity and mortality of cardiovascular diseases (CVD) in patients with rheumatoid arthritis (RA) is significantly higher than those in the general population, leading to RA-related CVD has attracted broad attention and numerous articles have been published. However, no study has systematically examined this area from a scientometric perspective. This study aimed to visualize the knowledge structure and identify emerging research trends and potential hotspots in this field.
Materials And Methods:
Articles and reviews on RA-CVD published from 2001 to 2021 were extracted from the Web of Science Core Collection database. CiteSpace and VOSviewer software were used to visualize the knowledge network of countries, institutions, authors, references and keywords in this field. SPSS and Microsoft Excel software were used for curve fitting and correlation analysis.
Results:
A total of 2,618 articles and reviews were included. The number of publications about RA-related CVD significantly increased yearly. Publications were mainly concentrated in North America, Europe and East Asia. The United States contributed most with 699 publications, followed by the United Kingdom and Italy. Gross Domestic Product was an important factor affecting scientific output. University of Manchester and Professor Kitas George D. were the most prolific institutions and influential authors, respectively. Journal of Rheumatology was the most productive journal for RA-related CVD research. The research hotspots switched in the order of clinical features (cardiovascular events), mechanism exploration, anti-tumor necrosis factor therapy, risk factors, and antirheumatic drug safety, which can be observed from the keyword analysis and co-cited reference cluster analysis.
Conclusions:
This study found that research on RA-related CVD is flourishing. The safety and cardiovascular pharmacological mechanisms of anti-rheumatoid drugs, especially targeted synthetic DMARDs, would be the focus of current research and developmental trends in future research.
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