Effect of an External Abdominal Compression Device on Polyp Detection during Colonoscopy

Area of Science:

• Gastroenterology
• Endoscopy
• Medical Devices

Background:

• ColoWrap is an external abdominal compression device designed to reduce looping and procedure time during colonoscopy.
• The impact of abdominal compression on polyp detection, specifically adenoma detection rate (ADR) and sessile serrated polyp detection rate (SSPDR), remains unclear.

Purpose of the Study:

• To determine if the use of ColoWrap during colonoscopy affects adenoma detection rate (ADR) or sessile serrated polyp detection rate (SSPDR) compared to a sham device.
• To investigate potential subgroup differences in polyp detection associated with ColoWrap use.

Main Methods:

• A single-center, randomized trial involving 350 participants aged 40-80.
• Participants were randomized to receive either ColoWrap or a sham device applied to the lower abdomen during colonoscopy.
• Adenoma detection rate (ADR) and sessile serrated polyp detection rate (SSPDR) were compared between groups using multivariable logistic regression.

Main Results:

• No significant overall differences in ADR (43% vs. 40%) or SSPDR (8% vs. 6%) were observed between the ColoWrap and sham groups.
• Subgroup analysis revealed increased odds of adenoma detection with ColoWrap in women, individuals over 60, and those with a BMI of 30-40.
• ColoWrap use was associated with increased ADR in the left colon (29% vs. 22%) and increased SSPDR in the cecum/ascending colon (6% vs. 2%).

Conclusions:

• ColoWrap use during colonoscopy does not negatively impact overall ADR or SSPDR.
• The device may improve polyp detection in specific colon segments and certain patient demographics.
• Results should be interpreted with caution due to the study's small sample size.