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Related Experiment Video

Updated: Sep 1, 2025

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Cerebellar and brainstem differences in children with developmental coordination disorder: A voxel-based morphometry

Kamaldeep K Gill1,2, Donna Lang2,3, Jill G Zwicker2,4,5

  • 1Department of Rehabilitation Sciences, The University of British Columbia, Vancouver, BC, Canada.

Frontiers in Human Neuroscience
|August 15, 2022
PubMed
Summary
This summary is machine-generated.

Children with developmental coordination disorder (DCD) show reduced grey matter volume in the cerebellum. This cerebellar difference is linked to poorer motor skills, potentially explaining learning difficulties in DCD.

Keywords:
cerebellumdevelopmental coordination disordergrey mattermotor skills disordervoxel-based morphometry

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Area of Science:

  • Neuroscience
  • Developmental Pediatrics
  • Radiology

Background:

  • Developmental Coordination Disorder (DCD) impacts motor skill acquisition and daily activities.
  • Altered brain structure and function are suspected in children with DCD.
  • The cerebellum's role in DCD is hypothesized but not extensively studied.

Purpose of the Study:

  • To investigate cerebellar structural differences in children with DCD compared to typically developing children.
  • To identify specific cerebellar regions affected in DCD.

Main Methods:

  • Voxel-based morphometry (VBM) was used to analyze cerebellar morphology.
  • High-resolution T1-weighted MRI scans were acquired from 46 children (34 with DCD, 12 controls) aged 8-12.
  • The Spatially Unbiased Atlas Template of the Cerebellum and Brainstem (SUIT) toolbox facilitated region-of-interest analysis.

Main Results:

  • Children with DCD exhibited reduced grey matter volume in multiple cerebellar lobules (brainstem, crus I, crus II, VI, VIIb, VIIIa).
  • A significant positive correlation was found between motor performance scores and grey matter volume in specific cerebellar regions (brainstem, crus I, VIIb, VIIIa).

Conclusions:

  • Reductions in cerebellar grey matter volume are associated with impaired motor skills in children with DCD.
  • These findings support the cerebellum's involvement in motor learning deficits observed in DCD.
  • The study provides neuroanatomical insights into the challenges children with DCD face in acquiring motor skills.