Influence of hexachlorobenzene on thyroids of male hamsters

The effect of hexachlorobenzene (HCB) on thyroid function in hamsters was explored and compared with that of 3-amino-1,2,4-triazole. Both chemicals caused thyroid enlargement but whereas 3-amino-1,2,4-triazole depressed serum thyroxine (T4) levels and elevated triiodothyronine (T3), HCB depressed T3 with little effect on T4.