Related Experiment Video
Updated: Sep 1, 2025
09:43
Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses
Published on: March 8, 2024
1.8K
Atypical HUS Triggered by COVID-19: A Case Report
Vaibhav Tiwari1, Gaurav Bhandari1, Anurag Gupta1
1Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India.
Indian Journal of Nephrology
|August 15, 2022
Summary
Coronavirus disease 2019 (COVID-19) can trigger atypical hemolytic uremic syndrome (aHUS). Genetic analysis revealed complement system mutations, necessitating simultaneous liver and kidney transplants to prevent recurrence.
Area of Science:
- Nephrology
- Infectious Diseases
- Genetics
Background:
- Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening condition characterized by thrombotic microangiopathy.
- Coronavirus disease 2019 (COVID-19) has been associated with various thrombotic complications, including kidney injury.
Observation:
- A 26-year-old male with COVID-19 presented with acute kidney injury and biopsy findings consistent with thrombotic microangiopathy.
- Plasmapheresis treatment did not lead to kidney function recovery.
Findings:
- Genetic analysis identified mutations in complement factor H-related proteins (CFHR1 and CFHR3), confirming a diagnosis of aHUS.
- The patient's aHUS was precipitated by COVID-19 infection.
Implications:
- This case highlights the potential for COVID-19 to trigger aHUS in genetically susceptible individuals.
- Simultaneous liver and kidney transplantation is recommended due to the high risk of aHUS recurrence after live-related kidney transplantation.
More Related Videos
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
21
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
21
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
55
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
55
01:27Acute Pyelonephritis I: Introduction
40
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
40
01:29Acute Kidney Injury II: Pathophysiology
63
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
63
01:29Acute Kidney Injury III: Clinical Manifestations
75
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
75
01:25Urinary Tract Infection II: Pathophysiology
33
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
33