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A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
Published on: January 27, 2019
Update on Pediatric Sepsis in Mexico
Crisell Arely Donath Benitez1, Estefanía Mattenberger-Cantú2,3, Ricardo Salas-Flores1
1Instituto Mexicano del Seguro Social, Ciudad Madero, Tamaulipas, Mexico.
Abstract:
The main objective of this work was to determine and update the causal agents' antibiotic sensitivity and resistance patterns on pediatric sepsis in a population of northeast Mexico. It is a cross-sectional study showing the results of blood cultures of pediatric patients with a presumptive diagnosis of sepsis were reviewed according to the SOFA criteria during 2020 in a public hospital in Mexico. A total of 207 blood cultures were performed and analyzed. The main isolated microorganisms were Staphylococcus, followed by Klebsiella and Escherichia. Several microorganisms showed 100% of sensitivity to different antibiotics or antifungals, some of them include Vancomycin, Voriconazole, Meropenem, Ciprofloxacin, and Cefotaxime. Bacteria of genre Staphylococcus showed its highest sensitivity rate to Tigecycline with 63.3%. Too Staphylococcus showed the highest resistance rate to Oxacillin with 50%. Although the patterns of sepsis-causing germs are similar to those previously reported, the development of new drugs with greater efficacy is the main contribution.
Insights
This study analyzed antibiotic resistance in pediatric sepsis in Mexico, finding common bacteria like Staphylococcus and Klebsiella. While some antibiotics remain effective, emerging resistance highlights the need for new drug development.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Pediatrics
Background:
- Pediatric sepsis remains a significant global health concern.
- Understanding local antibiotic resistance patterns is crucial for effective treatment.
- Northeast Mexico's specific microbial landscape requires updated data.
Purpose of the Study:
- To determine current antibiotic sensitivity and resistance patterns of causative agents in pediatric sepsis.
- To update epidemiological data for sepsis management in northeast Mexico.
- To identify effective antibiotics and areas of emerging resistance.
Main Methods:
- Cross-sectional study analyzing blood cultures from pediatric patients with sepsis (SOFA criteria).
- Review of 207 blood cultures performed in 2020 at a public hospital in Mexico.
- Identification of isolated microorganisms and assessment of their sensitivity/resistance to various antibiotics and antifungals.
Main Results:
- Staphylococcus, Klebsiella, and Escherichia were the most frequently isolated microorganisms.
- 100% sensitivity was observed for Vancomycin, Voriconazole, Meropenem, Ciprofloxacin, and Cefotaxime against certain pathogens.
- Staphylococcus exhibited 63.3% sensitivity to Tigecycline and a 50% resistance rate to Oxacillin.
Conclusions:
- Current sepsis-causing germ patterns are similar to previous reports.
- The study underscores the continued efficacy of certain broad-spectrum antibiotics.
- There is a clear need for the development of novel antimicrobial agents to combat evolving resistance.
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