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Time-Restricted Ketogenic Diet in Huntington's Disease: A Case Study.

Matthew C L Phillips¹, Eileen J McManus¹, Martijn Brinkhuis²

¹Department of Neurology, Waikato Hospital, Hamilton, New Zealand.

Frontiers in Behavioral Neuroscience

|August 15, 2022

Summary

A time-restricted ketogenic diet (TRKD) may improve symptoms in Huntington's disease (HD) patients. This case study shows significant improvements in motor function, daily living, and behavior for an HD patient on a TRKD.

Keywords:

Huntington's disease energy metabolism fasting ketogenic diet metabolic strategy mitochondria dysfunction neurodegeneration

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Area of Science:

Neuroscience
Metabolic Disorders
Mitochondrial Biology

Background:

Huntington's disease (HD) is a fatal neurodegenerative disorder with limited therapeutic options.
Mitochondrial dysfunction is a key factor in HD pathogenesis, affecting brain and skeletal muscle.
Metabolic interventions like ketogenic diets may enhance cellular energy production and mitochondrial function.

Observation:

A 41-year-old male with progressive HD adopted a time-restricted ketogenic diet (TRKD) for 48 weeks.
The patient experienced notable improvements in motor symptoms, daily activities, and behavioral issues.
Cognitive function did not show improvement, and weight remained stable with no adverse effects.

Findings:

The patient demonstrated a 52% improvement in motor symptoms and a 28% improvement in activities of daily living.
A 20% improvement in the composite Unified HD Rating Scale (cUHDRS) score was observed.
Significant improvements were noted in HD-related behavioral problems (50-100%) and quality of life (25%).

Implications:

This case suggests TRKD may be a viable complementary strategy for managing HD symptoms.
Further research into metabolic interventions for neurodegenerative diseases like HD is warranted.
TRKD could offer a potential pathway to improve clinical outcomes and quality of life for HD patients.