Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Problems in antifungal chemotherapy.

D A Stevens

    Infection
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    New antifungal chemotherapy agents are emerging, but challenges remain in efficacy and novel action. Improved diagnosis, standardized testing, and targeted therapies are crucial for managing difficult fungal infections.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Molecular epidemiology of global Candida dubliniensis isolates utilizing genomic-wide, co-dominant, PCR-based markers for strain delineation.

    Medical mycology·2009
    Same author

    In vitro activity of amphotericin B against Aspergillus terreus isolates from different countries and regions.

    Journal of chemotherapy (Florence, Italy)·2009
    Same author

    Frequency of paradoxical effect with caspofungin in Candida albicans.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2009
    Same author

    Conventional or molecular measurement of Aspergillus load.

    Medical mycology·2008
    Same author

    Temporal expression of inflammatory mediators in brain basilar artery vasculitis and cerebrospinal fluid of rabbits with coccidioidal meningitis.

    Clinical and experimental immunology·2006
    Same author

    The contribution of animal models of aspergillosis to understanding pathogenesis, therapy and virulence.

    Medical mycology·2005
    Same journal

    Double agent: how Escherichia coli switches from commensal to pathogen in the urinary tract infection.

    Infection·2026
    Same journal

    Metagenomic next-generation sequencing assists in identifying neurosyphilis: a case series.

    Infection·2026
    Same journal

    Chlamydia trachomatis infection among women with spontaneous abortion in Uganda: burden, clinical presentation, and associated factors in a hospital-based cross-sectional study.

    Infection·2026
    Same journal

    Performance of ultra-sensitive electrochemiluminescence LAM assay for diagnosing tuberculosis in HIV-negative individuals: a multicentre, prospective diagnostic study.

    Infection·2026
    Same journal

    Prehospital blood cultures in suspected sepsis: no need to wait until hospital arrival!

    Infection·2026
    Same journal

    Epidemiological trends of invasive Streptococcus pyogenes infections in Catalonia, 2022-2024: a two-year analysis.

    Infection·2026
    See all related articles

    Area of Science:

    • Mycology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Antifungal chemotherapy is rapidly evolving with new agent introductions.
    • Current challenges include the need for more effective antifungals with novel mechanisms of action.

    Purpose of the Study:

    • To highlight current challenges and future directions in antifungal chemotherapy.
    • To emphasize the need for improved diagnostic methods and standardized susceptibility testing.

    Main Methods:

    • Literature review and analysis of current trends in antifungal chemotherapy.
    • Identification of problem areas and unmet needs in managing fungal infections.

    Main Results:

    • Need for more effective antifungal agents with novel modes of action.

    Related Experiment Videos

  • Importance of early diagnosis and improved literature terminology.
  • Requirement for standardized in vitro susceptibility testing and clinical correlation studies.
  • Specific challenges in treating deep Candida infections, zygomycosis, fungal endocarditis/meningitis, cryptococcosis in AIDS, and Fusarium ocular infections.

    • Conclusions:

    • Further research is needed for better antifungal agents, diagnostic tools, and treatment protocols.
    • Exploring immunomodulating agents and improving prophylactic strategies are potential future avenues.
    • Resourceful management of existing agents to minimize toxicity is essential until advances occur.