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Suspected opioid-induced hyperalgesia in an infant following surgery: A case report

Proshad N Efune1,2, Sarah E Rebstock1

  • 1Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Journal of Clinical Pharmacy and Therapeutics
|August 15, 2022
PubMed

Insights

Opioid-induced hyperalgesia (OIH) in infants is challenging to diagnose. This case study suggests ketamine may effectively treat OIH in infants experiencing worsening pain post-surgery despite increased opioid doses.

Area of Science:

  • Pediatric Anesthesiology
  • Pain Management
  • Pharmacology

Background:

  • Opioids are frequently used for infant surgical pain management.
  • Opioid-induced hyperalgesia (OIH) is a recognized adverse effect in adults, but identification in infants is complex.
  • Postoperative pain management in infants requires careful consideration of opioid side effects.
Abstract

Keywords:
infantsopioidpain

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