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Controlling enzyme reactions by supramolecular protection and deprotection of oligosaccharide substrates

Milad Zangiabadi¹, Yan Zhao¹

¹Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, USA. zhaoy@iastate.edu.

Chemical Communications (Cambridge, England)

|August 15, 2022

Abstract:

Protection/deprotection is a powerful strategy in the total synthesis of complex organic molecules but similar tools are nearly absent in enzymatic reactions. We here report supramolecular protective receptors that outcompete an enzyme in the binding of oligosaccharides. The strong binding inhibits the enzymatic reaction and addition of an even stronger ligand for the receptor releases the substrate. These receptors could be used to control products from the same substrate/enzyme mixture and regulate enzymatic reactions reversibly.

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