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A New Optokinetic Testing Method to Measure Rat Vision.

Faizah Ahmed1, Deepthi S Rajendran Nair1, Biju B Thomas2

  • 1Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California.

Journal of Visualized Experiments : Jove
|August 15, 2022
PubMed
Summary

A new, affordable setup measures rat visual acuity using optokinetic nystagmus (OKN). This method reliably assesses vision in normal and degenerated rat models.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Animal Models

Background:

  • Optokinetic nystagmus (OKN) is a reflexive eye movement crucial for visual function assessment in rodents.
  • Existing methods for measuring OKN in rats can be complex or costly.

Purpose of the Study:

  • To develop a simple, inexpensive apparatus for recording OKN responses in rats.
  • To establish a reliable method for assessing visual acuity in normal and retinal degenerate rats.

Main Methods:

  • Utilized two tablet screens displaying high-contrast stripes generated by free web application software.
  • A clear Plexiglass holder restricted rat movement, ensuring consistent head orientation towards the display.
  • A micro-camera recorded head-tracking movements for quantitative analysis of OKN responses.

Main Results:

  • The apparatus enabled reliable measurement of OKN responses across different spatial frequencies.
  • Visual acuity was successfully determined in both normal and retinal degenerate rat models.
  • The technique proved effective for quantitative assessment of visual function.

Conclusions:

  • A novel, cost-effective apparatus for measuring visual acuity via OKN in rats has been demonstrated.
  • This method offers a reliable tool for research involving visual function in rodent models.
  • The findings support the utility of this technique for studying normal and impaired vision.